Spontaneous fMRI signal: What’s in it for me?

 

Dr. Jonathan D. Power, M.D., Ph.D.

National Institute of Mental Health

 

 

 

Abstract

A substantial fraction of fMRI studies are now entirely or partially “functional connectivity” studies, which use spontaneous, “task-free” fMRI signals as the substrates of analysis. Many cognitive neuroscientists will grant that there is something to be found in these signals. But the origin and meaning of these signals is unclear. Further, there are difficulties finding the “signal” amidst the noise. This talk will touch on some methodological issues that are central to functional connectivity MRI studies and will consider what spontaneous fMRI signals “mean.” 

 

Biography

Dr. Power did his doctoral research at Washington University in Saint Louis under the mentorship of Steve Petersen. He is currently a post-doctoral fellow at the NIMH working with Alex Martin. His work has focused on using spontaneous fMRI signals to understand brain organization. One focus has been deriving representations of whole-brain networks from spontaneous fMRI signals, identifying important nodes, and examining the effects of brain lesions at those nodes on cognition. Another focus, spurred by work on pediatric subjects, has been the description of motion artifact in resting state fMRI and the development of methods to identify and counteract this artifact. Dr. Power is recognized as an authority on resting-state fMRI and his work has appeared in a number of high profile outlets, including Science, Nature Neuroscience, Neuron, and PNAS.   

 

Optional Readings

JD Power et al. Neuron 2014

JD Power et al. Neuroimage 2015

 

Light lunch will be served